This week, Novavax announced its updated COVID-19 protein-based vaccine, NVX-CoV2601 (Nuvaxovid), has been granted an EUL by the WHO for immunization against COVID-19 in individuals aged 12 years and older. This listing now clears the way for this vaccine to be an option for all 194 member states of the WHO.
“The WHO Emergency Use Listing of our up

Novavax's Updated COVID-19 Vaccine is Granted EUL by WHO

Discovery is the process of exploring new and unique molecules, compounds and biologics that may have the potential to treat or prevent disease. We consider variables such as disease prevalence, unmet medical needs and current treatment options when identifying a preclinical candidate (PCC).
It takes about 10 years for a new product to reach the ma

The journey of a molecule

Erica L. Mayer, MD, MPH, director, Breast Cancer Clinical Research, Dana-Farber and Brigham and Women’s Hospital, institute physician, Dana-Farber Cancer Institute, associate professor, medicine, Harvard Medical School, discusses findings from research investigating CDK4/6 inhibitors in patients with hormone receptor (HR)–positive, HER2-negative br

Dr Mayer on the Use of CDK4/6 Inhibitors in HR+/HER2– Breast Cancer

Serum cortisol has several associations with inflammatory marker features of depression and anxiety in young women with gynecologic cancer, according to the results of a study recently published in Supportive Care in Cancer.
Given the paucity of knowledge in this specific arena, researchers conducted a study to examine the associations between seru

Higher Cortisol Level Linked to Depression, Anxiety in Younger Women With Gynecologic Cancer

Patients with advanced clear cell renal cell carcinoma (ccRCC) from certain socioeconomic and demographic backgrounds are less likely to receive treatment with immunotherapy (IO) regimens, including Black, Hispanic, and uninsured patients, according to findings from a retrospective analysis presented at the 2023 Society of Urologic Oncology (SUO) A

Data Show Barriers to Immunotherapy Access in Clear Cell RCC Population

For people with inherited bleeding disorders, timely diagnosis and treatment are essential to reduce the risk of complications and mortality. However, ongoing challenges have hindered global efforts to identify individuals with these disorders. For example, findings suggest that only 40% of those with hemophilia have been identified globally.1
In a

Improving the Detection of Inherited Bleeding Disorders

This commentary briefly examines the use of certain words and expressions in the oncology domain and the potentially relevant implications of different interpretations by patients and their families from professionals employing this language, including academic authors, experts in health policy and biomedical ethics, and members of their own clinic

Patient and Family Interpretations of the Language of Cancer Care

What are recommendations to clinicians and health systems to help increase the identification of these patients?
Dr Byams: Our division partners with community-based organizations to increase awareness and early identification of bleeding disorders in girls and women. The Better You Know program, developed by the National Bleeding Disorders Foundat

Articles
Patient and Family Interpretations of the Language of Cancer Care
This commentary examines the use of words and expressions in the oncology domain and the implications of different interpretations by patients and their families from professionals employing this language, including academic authors and members of their clinical teams.
Read

Maurie Markman, MD

Below is the abstract of the article.
Read the full article PDF by clicking here
or on the link below.
Background
Small cell bladder cancer (SCBC) is a rare aggressive bladder cancer (BC) variant comprising <1% of BC. Recommended front-line etoposide and platinum chemotherapy for SCBC is extrapolated from small cell lung cancer (SCLCA) studies. Dat

Atezolizumab With Platinum and Etoposide Chemotherapy Followed by Cystectomy for Patients With Localized Small Cell Neuroendocrine Bladder Cancer

1. In this systematic review and network meta-analysis, mind-body exercise, moderate aerobic exercise combined with light strength exercise, and moderate aerobic exercise alone were more effective than passive controls in improving sleep quality in those with sleep disorders.
2. However, the most effective treatment for improving sleep quality was

Wellness Check: Sleep

Combining PSMA-PET and mpMRI results to diagnose clinically significant prostate cancer while excluding benign prostatic hyperplasia might be feasible, but false positives remain a concern.
“For PSMA-PET, the expression of PSMA in benign prostatic hyperplasia (BPH) tissue and its related positive reaction, which can reduce the specificity of diagno

BPH-Related False Positive Rate on PSMA-PET for Prostate Cancer Quantified

Latest News
Antibiotic De-Escalation: Is This the Right Outcome Measure?
The proposed clinical benefits of de-escalation has contributed to its lukewarm adoption in some settings. This article looks at the challenges in measuring the impact of de-escalation, and the ongoing search for more meaningful metrics to evaluate the success of antimicrobial

Antibiotics

Abstract:
Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compro

Cardiac arrest outcomes following intraosseous and intravenous access

The use of short-course hypofractionated radiotherapy in localized prostate cancer saw a continuous increase from 2004 to 2020, according to findings from a cohort study published in JAMA Oncology.
The rate of patients who underwent moderate hypofractionated radiotherapy went from 22.0% in 2004 to 45.0% in 2020 (P <.001). Additionally, the rate of

Data Show Short-Course Radiotherapy Increase in Prostate Cancer

Treatment outcomes remain dismal in patients with relapsed or refractory myeloid leukemia associated with Down syndrome (ML-DS), according to research published in Blood Advances.
“A clinically striking feature of primary ML-DS is a significantly more favorable prognosis compared to that of acute myeloid leukemia in children without DS
(5-year even

Poor Survival Outcomes Among Children With Relapsed/Refractory Myeloid Leukemia Associated With Down Syndrome

1. In this retrospective cohort study, postoperative mortality was similar regardless of gender concordance between patients and surgeons.
Evidence Rating Level: 2 (Good)
Surgical outcomes are influenced by many factors, including patient comorbidities, disease characteristics, and the quality of perioperative care. Researchers aimed to determine w

Patient/surgeon gender concordance not associated with differences in mortality after surgery in the United States

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<span>Other chlorhexidine dressings contain additives such as gluconic acid (CHG) &amp; acetic acid (CHA) which have potential to irritate the skin.</span>